Efficacy of oseltamivir in the treatment of patients infected with Covid-19.

Objective: The recent unprecedented pandemic caused by Sars-Cov-2 (the new coronavirus 2019), is threatening public health around the world. Although several studies have been performed, there is no identified treatment for Covid-19 patients. Here we assessed the efficacy of oseltamivir in combination therapy, by comparing two different therapeutic regimens in hospitalized patients, in improving outcomes and find better treatment for Covid-19 patients. Methods: This is a single-center retrospective cohort study of 285 confirmed Covid-19 in patients at (XXX). Depending on the date of admission, the patients were divided into two groups; group 1 (oseltamivir group) from February 20, 2020 to March 15, 2020 received Oseltamivir with routine regimen and group 2 (control group) from March 20, 2020 to April 20, 2020 received routine regimen alone that included Azithromycin 500 mg/day and Hydroxychloroquine 200 mg/12 h.Endpoints including duration of hospitalization, requirement to admission to intensive care unit (ICU) and mechanical ventilation, outcome and mortality rate. Results: A total of 285 patients were enrolled in the two months, 120 patients for group 1 and 165 for group 2. The median time from admission to discharge was significantly shorter in the oseltamivir group compared to the control group (4.9 vs 6.6 days, p < 0.001). Additionally, the mortality rate was found to be lower in the oseltamivir group than in the control group (1.7% vs 6,7%, p = 0.06) which was statistically significant by multivariate analysis (p = 0.03). The incidence of admission to the ICU (6.7% vs 11.5%, p = 0.1) and mechanical ventilation (2.5% vs 4.8%, p = 0.3) were also decreased in the oseltamivir group, but was not statistically significant. Conclusions: This study showed that administration of oseltamivir was associated with shorter length of hospital stay and earlier recovery and discharge of hospital, and a lower mortality rate.

Beach debris quantity and composition around the world: A bibliometric and systematic review.

Anthropogenic pollution of marine ecosystems caused by beach debris has become a serious environmental concern in the last few decades. Regarding the raising production of beach debris, the present work aimed to summarize the quantity and quality of beach debris reported from different beach areas of the world. Also, a bibliometric analysis was used to analyze research trends and upgrade knowledge in this research area. Using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), the eligible papers reviewed regarding beach debris abundance along with their composition from 2010, which were extracted from the Scopus database. The results of the study showed that plastic items represented the dominant material (61.25%), followed by food (5.88%), wood (5.78%), metals (5.2%), and glass (5%). Further, the beaches studied were classified into three degrees, including highly polluted (31.5 items/m2), moderate polluted (3.47 items/m2), and low polluted (0.37 items/m2), based on the average abundance of debris.

Dielectric barrier discharge plasma with photocatalysts as a hybrid emerging technology for degradation of synthetic organic compounds in aqueous environments: A critical review.

Dielectric barrier discharge (DBD) plasma has been recently used for removal of synthetic organic compounds (SOCs) from aqueous environments. The removal of SOCs by alone DBD is significantly limited by its high electricity needs and inefficient mineralization, which affects the further application of DBD for SOCs. The combined application of DBD with other technologies and the addition of a supplementary substance for energy-saving were proposed to resolve these problems. The addition of catalysts is considered to be a promising and innovative approach to increase the energy yield of DBD, improve the environment friendly of DBD, develop the variety of goal SOCs, and improve the removal efficiency of DBD system. Despite the increasing use of the coupling form of DBD and catalysts, as catalytic dielectric barrier discharge (CDBD), but it still requires a comprehensive review to summarize the last studies and highlight the future perspectives in this area. Therefore, this work is the first literature review aimed to critically assess the latest developments of catalysts coupling with DBD employed in aqueous environments. Moreover, performance evaluation, energy yield, toxicity, eco-friendly, and future perspectives of the CDBD systems for SOCs removal were discussed and overviewed. The results showed that the coupling of catalysts with DBD presents synergistic effects and had excellent removal performance for aqueous SOCs. Overall, it can be concluded that the essential principles of environmental and economic sustainability have been addressed for the removal of persistent pollutants from aqueous environments in the CDBD systems.

The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: A randomized controlled trial.

BACKGROUND AND AIMS: Inflammation and proliferation are the cause of benign prostatic hyperplasia (BPH) and are the key components of its mechanism of action. In this study we sought to determine the role of 25-hydroxyvitamin D in BPH, because of its anti-inflammatory activities, and its effect on prostate volume and BPH symptoms. METHODS: This randomized clinical trial (RCT) was conducted on 108 participants >50 years of age who had either asymptomatic or mild BPH symptoms according to the International Prostate Symptom Score (IPSS) questionnaire. Patients were randomly divided into two groups, intervention and control. The intervention group received 50 000 units of vitamin D3 and the control group received a placebo every two weeks for six months. Prostate ultrasound, routine clinical examinations, toucher rectal (TR), and laboratory tests were performed for all patients. After six months, the patients underwent another ultrasound evaluation, measurement of prostate-specific antigen (PSA) levels and completed the IPSS. Results of the evaluations before and after the intervention were compared between the groups using the chi-square, t-test, and logistic regression analysis. Repeated measure analysis was used to evaluate the effect of vitamin D intervention on the changes in the IPSS score. RESULTS: The mean age of the participants was 56 ± 9 years. In the control group, the mean prostate volume was higher compared to the intervention group (p < 0.001). The control group had a higher mean PSA level than the intervention group (p < 0.001). Although the IPSS score decreased over time in both groups, analysis of variance showed that the amount of change or decrease in IPSS score in the intervention group was significantly more than the control group (p < 0.001). CONCLUSIONS: The results of our study support the effect of vitamin D in reducing prostate volume and PSA levels, and in improving BPH symptoms. Further studies are needed to confirm these findings to verify the use of vitamin D as a treatment for BPH.

Dynamic assessment of economic and environmental performance index and generation, composition, environmental and human health risks of hospital solid waste in developing countries; A state of the art of review.

Many studies have been conducted on hospital solid waste management (HSWM) throughout the world, especially developing countries. This interdisciplinary study aims to summarize the available knowledge on the health and environmental risks of hospital solid waste (HSW) and also, develop a dynamic associational assessment among hospital solid waste generation rate (HSWGR), hospital solid waste composition (HSWC), gross domestic product (GDP) per capita, and environmental performance index (EPI) in some developing countries for the first time. The results of this study showed that researchers from India, China, Pakistan, Brazil, and Iran had found more evidence about the health, economic, and environmental issues in HSW than the other developing countries. The literature showed that the highest and lowest reported HSWGR (in national average level) belonged to Ethiopia (6.03) and India (0.24) kg bed -1 day-1, respectively. It has also been shown that all studied countries except Serbia, have higher levels of hazardous waste in their HSWC, based on the WHO's standard. Furthermore, the quantity and quality of HSW in developing countries depend on the service provided by the hospital, type of hospital, HSWM system, and the level of regional economic and culture. The association analysis showed that the EPI and GDP per capita of developing countries were significantly (p-value <0.05) associated with HSWGR, non-hazardous HSW, and hazardous HSW by the Spearman coefficients equal to 0.389, 0.118, -0.118, and 0.122, 0.216, and -0.346, respectively. However, it can be concluded that GDP per capita and EPI have a weak correlation with hazardous HSW and non-hazardous HSW. Moreover, HSW has many hazardous health and environmental risks such as dioxin and furan, that must be controlled and managed through implementing programs and policies based on sustainable development. As a final point, we believed that the present study can be considered to be a guide for future studies on HSWM in developing countries.

Meteorological correlates and AirQ+ health risk assessment of ambient fine particulate matter in Tehran, Iran.

There are few studies in the world that have been evaluated the mortality due to exposure to particulate matter smaller than 2.5 µm by AirQ+ software. Therefore, the study aimed to correlate between fine particulate matter (PM2.5) and meteorological variables and estimate all-cause annual mortality and mortality from cerebrovascular disease (stroke), ischemic heart disease (IHD), acute lower respiratory infection (ALRI), lung cancer (LC), chronic obstructive pulmonary disease (COPD) attributed to long-term exposure to ambient PM2.5 in Tehran from March 2017 to March 2018 using the WHO AirQ+ software. Data related to air quality, meteorological condition, population and the baseline incidence rates of health endpoints in Tehran were gathered from government agencies. The association between the PM2.5 concentrations and meteorological variables in the period of study were assessed by correlation analysis. The results of correlation analysis showed a weak positive correlation between PM2.5 concentrations and average monthly temperature (r = 0.42, P < 0.05) and average monthly humidity (r = 0.37, P < 0.05) in Tehran. The quantitative risk assessment related to all-cause annual mortality, the mortality of IHD, stroke, COPD, LC and ALRI were estimated 6710, 3797, 1145, 172, 135 and 27 cases, respectively. The results of regression association analysis between PM2.5 and the number of recorded deaths was showed that with an increase of one microgram per cubic meter of PM2.5, it is expected that about 27 cases will be added to air pollution mortality in Tehran.

Quantitative and qualitative analysis of construction and demolition waste in Yazd city, Iran.

Construction and demolition waste is the major category of municipal solid waste that is important due to high volume and mass produced. Therefore, this study aims to analyze the quantitative and qualitative of construction and demolition waste in Yazd. This descriptive cross-sectional study was conducted on a waste disposal site in Yazd in 2017-2018. sampling of the construction and demolition waste disposal site was performed for 12 months (Jul 2017 to Jul 2018). According to a researcher-made checklist, data on the weight, the density and volume of these wastes were collected. The descriptive statistics tests of data were processed in Excel software. 53,445 t of waste are annually generated in Yazd that the amount of cement and concrete, bricks, tile and ceramic (TC), ferrous metals, non-ferrous metals, glass, plastic, wood, and are approximately 38%, 20%, 14%, 11%, 6%, 5%, 3%, and 3%, respectively. With regards to the high volume of waste generated and a remarkable part of the recyclable waste, urban planners should pay attention to the implementation of waste reduction and recycling programs.

A comparative study of anaerobic fixed film baffled reactor and up-flow anaerobic fixed film fixed bed reactor for biological removal of diethyl phthalate from wastewater: a performance, kinetic, biogas, and metabolic pathway study.

BACKGROUND: Phthalic acid esters, including diethyl phthalate (DEP), which are considered as top-priority and hazardous pollutants, have received significant attention over the last decades. It is vital for industries to select the best treatment technology, especially when the DEP concentration in wastewater is high. Meanwhile, anaerobic biofilm-based reactors are considered as a promising option. Therefore, in the present study, for the biological removal of DEP from synthetic wastewater, two different anaerobic biofilm-based reactors, including anaerobic fixed film baffled reactor (AnFFBR) and up-flow anaerobic fixed film fixed bed reactor (UAnFFFBR), were compared from kinetic and performance standpoints. As in the previous studies, only the kinetic coefficients have been calculated and the relationship between kinetic coefficients and their interpretation has not been evaluated, the other aim of the present study was to fill this research gap. RESULTS: In optimum conditions, 90.31 and 86.91% of COD as well as 91.11 and 88.72% of DEP removal were achieved for the AnFFBR and UAnFFFBR, respectively. According to kinetic coefficients (except biomass yield), the AnFFBR had better performance as it provided a more favorable condition for microbial growth. The Grau model was selected as the best mathematical model for designing and predicting the bioreactors' performance due to its high coefficients of determination (0.97 < R2). With regard to the insignificant variations of the calculated Grau kinetic coefficients (KG) when the organic loading rate (with constant HRT) increased, it can be concluded that both of the bioreactors can tolerate high organic loading rate and their performance is not affected by the applied DEP concentrations. CONCLUSIONS: Both the bioreactors were capable of treating low-to-high strength DEP wastewater; however, according to the experimental results and obtained kinetic coefficients, the AnFFBR indicated higher performance. Although the AnFFBR can be considered as a safer treatment option than the UAnFFFBR due to its lower DEP concentrations in sludge, the UAnFFFBR had lower VSS/TSS ratio and sludge yield, which could make it more practical for digestion. Finally, both the bioreactors showed considerable methane yield; however, compared to the UAnFFFBR, the AnFFBR had more potential for bioenergy production. Although both the selected bioreactors achieved nearly 90% of DEP removal, they can only be considered as pre-treatment methods according to the standard regulations and should be coupled with further technology.

Performance, kinetic, and biodegradation pathway evaluation of anaerobic fixed film fixed bed reactor in removing phthalic acid esters from wastewater.

Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine disrupting effects on human health. Industrial wastewater has been reported as an important environment with high concentrations of PAEs. In the present study, four short-chain PAEs including diallyl phthalate (DAP), diethyl phthalate (DEP), dimethyl phthalate (DMP), and phthalic acid (PA) were selected as a substrate for anaerobic fixed film fixed bed reactor (AnFFFBR). The process performances of AnFFFBR, and also its kinetic behavior, were evaluated to find the best eco-friendly phthalate from the biodegradability point of view. According to the results and kinetic coefficients, removing and mineralizing of DMP occurred at a higher rate than other phthalates. In optimum conditions 92.5, 84.41, and 80.39% of DMP, COD, and TOC were removed. DAP was found as the most bio-refractory phthalate. The second-order (Grau) model was selected as the best model for describing phthalates removal.